Embryo survival gene may fight range of diseases: study












HONG KONG (Reuters) – A gene that keeps embryos alive appears to control the immune system and determine how it fights chronic diseases like hepatitis and HIV, and autoimmune diseases like rheumatoid arthritis, scientists said on Monday.


Although the experts have only conducted studies on the gene Arih2 using mice, they hope it can be used as a target for drugs eventually to fight a spectrum of incurable diseases.












Lead author Marc Pellegrini at the Walter and Eliza Hall Institute of Medical Research in Australia said the gene appears to act like a switch, flipping the immune system on and off.


“If the gene is on, it dampens … the immune response. And if you switch it off, it greatly enhances immune responses,” Pellegrini said in a telephone interview.


“It is probably one of the few genes and pathways that is very targetable and could lead to a drug very quickly.”


Arih2 was first identified by another group of scientists in the fruit fly but it drew the interest of Pellegrini’s team because of its suspected links to the immune system.


In a paper published in Nature Immunology, Pellegrini and his team described how mice embryos died when the gene was removed.


Next, they removed the gene from adult mice and noticed how their immune systems were boosted for a short period of time. But it quickly went into an overdrive and started attacking the rodents’ own healthy cells, skin and organs.


“The mice survived for six weeks quite well. Then they started developing this very hyperactive immune responses and if you leave it for too long, it starts reacting against the body itself,” Pellegrini said.


Pellegrini and his colleagues hope that scientists can study the gene further and use it as a drug target to fight a large spectrum of diseases.


“It’s like an accelerator. In infectious diseases, you want to slam on the brakes on this gene, and for autoimmune diseases, you want to push the accelerator to make it work much harder to stop the whole immune response,” said Pellegrini.


“The more the gene works, the less of an immune response there is. And the less active the gene is, the more the immune response is.”


(Reporting by Tan Ee Lyn; Editing by Nick Macfie)


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Prankster Replicates Facebook Users’ Profile Photos, Then Friends Targets [PICS]












1.


Image courtesy of Imgur, casinoroycasinoroy


Click here to view this gallery.












[More from Mashable: This App Curates Gifts From Startups for Your Trendy Friends]


Everyone has a knack for something. Reddit user CasinoRoy’s talent is creeping out strangers on Facebook, and perfectly replicating their profile photos.


[More from Mashable: Facebook to Slow Down After Move to HTTPS [VIDEO]]


The prankster searches for Facebook users with his name, and then recreates their profile photos by imitating their wardrobe and facial expression. When it’s all done, he sends the subject a friend request.


In total, CasinoRoy found eight people on Facebook with his name. He recently shared his hilarious project to Reddit, which garnered 20,000 views in four hours. The joker revealed on Reddit that only one person accepted his friend request. The relationship was short-lived. “He seemed genuinely creeped out and de-friended me shortly after,” he wrote.


What would you do if you found a perfect replica of your Facebook profile picture? Tell us in the comments below.


Image courtesy of Imgur, casinoroycasinoroy


This story originally published on Mashable here.


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“Downton Abbey” Renewed for fourth Season by ITV












LOS ANGELES (TheWrap.com) – “Downton Abbey” fans have something to be thankful for.


British network ITV has commissioned a fourth season of the hit historical drama, the network said Friday. The new season will consist of eight new episodes to premiere in fall 2013, with an extended episode for Christmas 2013. As with previous seasons, the opening and closing episodes will be feature-length.












“Downton Abbey” Season 4 will begin filming in February at Highclere Castle and Ealing Studios.


Noting that the upcoming season will see the inclusion of some new faces, “Downton Abbey” executive producer Gareth Neame said, “Viewers can look forward to more drama, comedy, love, hatred, jealousy, rivalry, ambition, despair and romance.”


Produced by NBC Universal’s Carnival Film & Television, the Emmy and Golden Glove-winning “Downton Abbey” airs on PBS in the U.S.


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Tourists visit Texas ranch to remember 'Dallas' star Larry Hagman

PARKER, Texas (AP) — Tourists and locals flocked to Southfork Ranch on Saturday, bringing flowers in memory of Larry Hagman, who played the infamous J.R. Ewing on the TV show "Dallas."

Hagman died in Dallas on Friday at age 81 due to complications from his battle with cancer.

Southfork, a ranch north of Dallas, was known to millions of viewers as the Ewing family home. Exterior shots of the house and pool were shown when the series aired from 1978 to 1991, although the show wasn't filmed there.

The ranch has been open for tours since the mid-1980s, and now sees more than 100,000 visitors each year. Each room of the house has a theme for each character.

On Saturday, J.R. Ewing's room had flowers and a card for tourists to sign.

"Today is about Larry Hagman and his family," said Janna Timm, a Southfork Ranch & Hotel spokeswoman. "He was such a wonderful person, and we will really miss him."

"Dallas" was recently revived on TNT this summer, and all of the scenes were filmed at Southfork or other places in the Dallas area. Hagman had revised his role as the scheming oilman who would even double-cross his own son.

Linda Sproule of Peterborough, Ontario, had been traveling through the U.S. the past couple of weeks and heard about Hagman's death Friday while in Dallas. She said she didn't know where Southfork was but wanted to come because she was a fan of the show in the 1980s.

"I remember on Friday nights we watched it, and J.R. was bigger than life in some ways," she said after taking the Southfork tour Saturday morning. "This ranch is beautiful. Being here is kind of emotional in a way."

Barbara Quinones and her husband were in town for their daughter's soccer tournament and had already planned to visit Southfork when they heard news of Hagman's death.

"We loved him because he was so ruthless," said Quinones, of Albuquerque, N.M. "This is a sad day, but I'm glad we're here."

Some of the show's stars, including Hagman, came to Southfork for the series' 25th anniversary. The Fort Worth-born actor also had visited several times before the show was revived.

"He was definitely a gentleman, a class act," said Jim Gomes, vice president of resorts at Southfork Ranch & Hotel. "He loved the fans as much as they loved him."

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Saudi royals, officials visit king in hospital after surgery












JEDDAH, Saudi Arabia (Reuters) – Senior Saudi royals and government officials have visited King Abdullah in hospital, state news agency SPA reported, a week after the monarch – believed to be in his late 80s – had surgery to tighten a ligament in his back.


The stability of the world’s biggest oil exporter and an important regional U.S. ally is of global concern as the kingdom holds more than a fifth of the world’s crude reserves and is a venue for millions of Muslim pilgrims every year.












SPA’s report on Saturday carried a photograph of officials and royals gathered inside the National Guard‘s King Abdulaziz Medical City in Riyadh, but did not say who was allowed to see the king or when he is expected to leave hospital.


The king was admitted for surgery on November 16 and an announcement from the Royal Court said that he had undergone a successful back operation that lasted for 11 hours. No photographs of Abdullah have been released.


Saudi analysts said on Saturday it was understandable that he would take time to recover, given his age.


Abdullah underwent a similar operation in October last year and had back surgery twice in the United States in 2010 for a herniated disc, after which spent three months outside Saudi Arabia recuperating.


After his back operation last year, Abdullah appeared on state television two days after his surgery and was released from hospital within five days of the operation.


Investors attributed Saudi stock market selling last week to worries over the king’s health. The benchmark index fell 3 percent in the trading week ending on Wednesday and fell 1.4 percent on Sunday after a 0.8 percent bounce on Saturday.


The crown has passed down a line of the sons of the kingdom’s founder King Abdulaziz Ibn Saud, who died in 1953.


Abdullah – who took power in 2005 – named his brother Prince Salman, 13 years his junior, heir apparent in June after the death of Crown Prince Nayef bin Abdulaziz.


Salman, who deputizes for the king, was shown on television last week meeting visiting U.S. officials. He also chaired the weekly cabinet meeting last Monday.


(Reporting by Asma Alsharif; Editing by Louise Ireland and Sami Aboudi)


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Cricket-Australia v South Africa – second test scoreboard












ADELAIDE, Nov 24 (Reuters) – Scoreboard at the close of the


third day of the second test between Australia and South Africa












at Adelaide Oval on Saturday:


Australia won the toss and chose to bat


Australia first innings 550


South Africa first innings


G. Smith c Wade b Siddle 122


A. Petersen run out 54


H. Amla st Wade b Warner 11


J. Rudolph c Quiney b Lyon 29


AB de Villiers lbw b Siddle 1


F. du Plessis c Clarke b Hilfenhaus 78


D. Steyn c Ponting b Hilfenhaus 1


R. Kleinveldt b Hilfenhaus 0


J. Kallis c Wade b Clarke 58


M. Morkel b Lyon 6


I. Tahir not out 10


Extras (b-7, lb-2, w-3, nb-6) 18


Total: (all out, 124.3 overs) 388


Fall of wickets: 1-138 2-169 3-233 4-233 5-240 6-246 7-250


8-343 9-352 10-388


Bowling: B. Hilfenhaus 19.3-6-49-3, J. Pattinson 9.1-0-41-0


(nb-4, w-1) N. Lyon 44-7-91-2, P. Siddle 30.5-6-130-2 (nb-2), M.


Clarke 7-1-22-1, M. Hussey 1-0-7-0 (w-2), D. Warner 5-0-27-1, R.


Quiney 8-3-12-0


Australia second innings


D. Warner c Du Plessis b Kleinveldt 41


E. Cowan b Kleinveldt 29


R. Quiney c De Villiers b Kleinveldt 0


R. Ponting b Steyn 16


M. Clarke not out 9


P. Siddle c De Villiers b Morkel 1


M. Hussey 5


Extras (lb-7, nb-3) 10


Total (for five wickets, 32 overs) 111


Fall of wickets: 1-77 2-77 3-91 4-98 5-103


Still to bat: M. Wade, B. Hilfenhaus, J. Pattinson, N. Lyon.


Bowling: Steyn 10-4-28-1, Morkel 9-2-24-1, Kleinveldt


6-1-14-3 (nb-2), Tahir 7-1-38-0 (nb-1)


- -


Third test: WACA, Perth Nov. 30-Dec. 4


(Compiled by Ian Ransom; Editing by Alastair Himmer)


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Secret message found with carrier pigeon may never be deciphered












 Secret message found with carrier pigeon may never be decipheredBritish man finds carrier pigeon skeleton in his fireplace with unbreakable secret code (Reuters)


Before military forces had secure cell phones and satellite communications, they used carrier pigeons. The highly trained birds delivered sensitive information from one location to another during  World War II. Often, the birds found the intended recipient. But not always.












A dead pigeon was recently discovered inside a chimney in Surrey, England. There for roughly 70 years, the bird had a curious canister attached to its leg. Inside was a coded message that has stumped the experts.


The code features a series of 27 groups of five letters. According to Reuters, nobody from Britain’s Government Communications Headquarters has been able to decipher it. The message was sent by a Sgt. W. Scott to someone or something identified as “Xo2.”


A spokesperson remarked, “Although it is disappointing that we cannot yet read the message brought back by a brave carrier pigeon, it is a tribute to the skills of the wartime code-makers that, despite working under severe pressure, they devised a code that was indecipherable both then and now.”


The bird was discovered by a homeowner doing renovations earlier this month. In an interview with Reuters, David Martin remarked that bits of birds kept falling from the chimney. Eventually, Margin saw the red canister and speculated that it might contain a secret message. And it seems as if the message will always be secret.


Carrier pigeons played a vital role in wars due to their incredible homing skills. All told, U.K. forces used about 250,000 of the birds during World War II.


Wireless News Headlines – Yahoo! News


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Larry Hagman dead at 81, portrayed notorious TV villain J.R. Ewing












(Reuters) – Larry Hagman, who created one of American television’s most supreme villains in the conniving, amoral oilman J.R. Ewing of “Dallas,” died on Friday, the Dallas Morning News reported. He was 81.


Hagman died at a Dallas hospital of complications from his battle with throat cancer, the newspaper said, quoting a statement from his family. He had suffered from liver cancer and cirrhosis of the liver in the 1990s after decades of drinking.












Hagman’s mother was stage and movie star Mary Martin and he became a star himself in 1965 on “I Dream of Jeannie,” a popular television sitcom in which he played Major Anthony Nelson, an astronaut who discovers a beautiful genie in a bottle.


Dallas,” which made its premiere on the CBS network in 1978, made Hagman a superstar. The show quickly became one of the network’s top-rated programs, built an international following and inspired a spin-off, imitators and a revival in 2012.


Dallas” was the night-time soap-opera story of a Texas family, fabulously wealthy from oil and cattle, and its plot brimmed with back-stabbing, double-dealing, family feuds, violence, adultery and other bad behavior.


In the middle of it all stood Hagman’s black-hearted J.R. Ewing – grinning wickedly in a broad cowboy hat and boots, plotting how to cheat his business competitors and cheat on his wife. He was the villain TV viewers loved to despise during the show’s 356-episode run from 1978 to 1991.


“I really can’t remember half of the people I’ve slept with, stabbed in the back or driven to suicide,” Hagman said of his character in Time magazine.


In his autobiography, “Hello Darlin’: Tall (and Absolutely True) Tales About My Life,” Hagman wrote that J.R. originally was not to be the focus of “Dallas” but that changed when he began ad-libbing on the set to make his character more outrageous and compelling.


‘WHO SHOT J.R.?’


To conclude its second season, the “Dallas” producers put together one of U.S. television’s most memorable episodes in which Ewing was shot by an unseen assailant. That gave fans months to fret over whether J.R. would survive and who had pulled the trigger. In the show’s opening the following season, it was revealed that J.R.’s sister-in-law, Kristin, with whom he had been having an affair, was behind the gun.


Hagman said an international publisher offered him $ 250,000 to reveal who had shot J.R. and he considered giving the wrong information and taking the money, but in the end, “I decided not to be so like J.R. in real life.”


The popularity of “Dallas” made Hagman one of the best-paid actors in television and earned him a fortune that even a Ewing would have coveted. He lost some of it, however, in bad oil investments before turning to real estate.


“I have an apartment in New York, a ranch in Santa Fe, a castle in Ojai outside of L.A., a beach house in Malibu and thinking of buying a place in Santa Monica,” Hagman said in a Chicago Tribune interview.


An updated “Dallas” series began in June 2012 on the TNT network with Hagman reprising his J.R. role with original cast members Linda Gray, who played J.R.’s long-suffering wife, Sue Ellen, and Patrick Duffy, who was his brother Bobby. The show was to focus on the sons of J.R. and Bobby.


Hagman had a wide eccentric streak. When he first met actress Lauren Bacall, he licked her arm because he had been told she did not like to be touched and he was known for leading parades on the Malibu beach and showing up at a grocery store in a gorilla suit. Above his Malibu home flew a flag with the credo “Vita Celebratio Est (Life Is a Celebration)” and he lived hard for many years.


In 1967, rock musician David Crosby turned him on to LSD, which Hagman said took away his fear of death, and Jack Nicholson introduced him to marijuana because Nicholson thought he was drinking too much.


Hagman had started drinking as a teenager and said he did not stop until the moment in 1992 when his doctor told him he had cirrhosis of the liver and could die within six months. Hagman wrote that for the past 15 years he had been drinking about four bottles of champagne a day, including while on the “Dallas” set.


LIVER TRANSPLANT


In July 1995, he was diagnosed with liver cancer, which led him to quit smoking, and a month later he underwent a liver transplant.


After giving up his vices, Hagman said he did not lose his zest for life.


“It’s the same old Larry Hagman,” he told a reporter. “He’s just a littler sober-er.”


Hagman was born on September 21, 1931, in Weatherford, Texas, and his father was a lawyer who dealt with the Texas oil barons Hagman would later come to portray. He was still a boy when his parents divorced and he went to Los Angeles with Martin, who would become a Broadway and Hollywood musical star.


Hagman eventually landed in New York to pursue acting, making his stage debut there in “The Taming of the Shrew.” In New York, he married Maj Axelsson in 1954 while they were in a production of “South Pacific. The marriage produced two children, Heidi and Preston.


Hagman served in the Air Force, spending five years in Europe as the director of USO shows, and on his return to New York he took a starring role in the daytime soap “The Edge of Night.” His breakthrough came in 1965 when he landed the “I Dream of Jeannie” role opposite Barbara Eden.


In his later years, Hagman became an advocate for organ transplants and an anti-smoking campaigner. He also was devoted to solar energy, telling the New York Times he had a $ 750,000 solar panel system at his Ojai estate, and made a commercial in which he portrayed a J.R. Ewing who had forsaken oil for solar power. He was a longtime member of the Peace and Freedom Party, a minor leftist organization in California.


Hagman told the Times that after death he wanted his remains to be “spread over a field and have marijuana and wheat planted and harvest it in a couple of years and then have a big marijuana cake, enough for 200 to 300 people. People would eat a little of Larry.”


(Writing by Bill Trott in Washington; Additional reporting by Alex Dobuszinkis in Los Angeles; Editing by Peter Cooney)


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Larry Hagman dead at 81, portrayed notorious TV villain J.R. Ewing

(Reuters) - Larry Hagman, who created one of American television's most supreme villains in the conniving, amoral oilman J.R. Ewing of "Dallas," died on Friday, the Dallas Morning News reported. He was 81.


Hagman died at a Dallas hospital of complications from his battle with throat cancer, the newspaper said, quoting a statement from his family. He had suffered from liver cancer and cirrhosis of the liver in the 1990s after decades of drinking.


Hagman's mother was stage and movie star Mary Martin and he became a star himself in 1965 on "I Dream of Jeannie," a popular television sitcom in which he played Major Anthony Nelson, an astronaut who discovers a beautiful genie in a bottle.


"Dallas," which made its premiere on the CBS network in 1978, made Hagman a superstar. The show quickly became one of the network's top-rated programs, built an international following and inspired a spin-off, imitators and a revival in 2012.


"Dallas" was the night-time soap-opera story of a Texas family, fabulously wealthy from oil and cattle, and its plot brimmed with back-stabbing, double-dealing, family feuds, violence, adultery and other bad behavior.


In the middle of it all stood Hagman's black-hearted J.R. Ewing - grinning wickedly in a broad cowboy hat and boots, plotting how to cheat his business competitors and cheat on his wife. He was the villain TV viewers loved to despise during the show's 356-episode run from 1978 to 1991.


"I really can't remember half of the people I've slept with, stabbed in the back or driven to suicide," Hagman said of his character in Time magazine.


In his autobiography, "Hello Darlin': Tall (and Absolutely True) Tales About My Life," Hagman wrote that J.R. originally was not to be the focus of "Dallas" but that changed when he began ad-libbing on the set to make his character more outrageous and compelling.


'WHO SHOT J.R.?'


To conclude its second season, the "Dallas" producers put together one of U.S. television's most memorable episodes in which Ewing was shot by an unseen assailant. That gave fans months to fret over whether J.R. would survive and who had pulled the trigger. In the show's opening the following season, it was revealed that J.R.'s sister-in-law, Kristin, with whom he had been having an affair, was behind the gun.


Hagman said an international publisher offered him $250,000 to reveal who had shot J.R. and he considered giving the wrong information and taking the money, but in the end, "I decided not to be so like J.R. in real life."


The popularity of "Dallas" made Hagman one of the best-paid actors in television and earned him a fortune that even a Ewing would have coveted. He lost some of it, however, in bad oil investments before turning to real estate.


"I have an apartment in New York, a ranch in Santa Fe, a castle in Ojai outside of L.A., a beach house in Malibu and thinking of buying a place in Santa Monica," Hagman said in a Chicago Tribune interview.


An updated "Dallas" series began in June 2012 on the TNT network with Hagman reprising his J.R. role with original cast members Linda Gray, who played J.R.'s long-suffering wife, Sue Ellen, and Patrick Duffy, who was his brother Bobby. The show was to focus on the sons of J.R. and Bobby.


Hagman had a wide eccentric streak. When he first met actress Lauren Bacall, he licked her arm because he had been told she did not like to be touched and he was known for leading parades on the Malibu beach and showing up at a grocery store in a gorilla suit. Above his Malibu home flew a flag with the credo "Vita Celebratio Est (Life Is a Celebration)" and he lived hard for many years.


In 1967, rock musician David Crosby turned him on to LSD, which Hagman said took away his fear of death, and Jack Nicholson introduced him to marijuana because Nicholson thought he was drinking too much.


Hagman had started drinking as a teenager and said he did not stop until the moment in 1992 when his doctor told him he had cirrhosis of the liver and could die within six months. Hagman wrote that for the past 15 years he had been drinking about four bottles of champagne a day, including while on the "Dallas" set.


LIVER TRANSPLANT


In July 1995, he was diagnosed with liver cancer, which led him to quit smoking, and a month later he underwent a liver transplant.


After giving up his vices, Hagman said he did not lose his zest for life.


"It's the same old Larry Hagman," he told a reporter. "He's just a littler sober-er."


Hagman was born on September 21, 1931, in Weatherford, Texas, and his father was a lawyer who dealt with the Texas oil barons Hagman would later come to portray. He was still a boy when his parents divorced and he went to Los Angeles with Martin, who would become a Broadway and Hollywood musical star.


Hagman eventually landed in New York to pursue acting, making his stage debut there in "The Taming of the Shrew." In New York, he married Maj Axelsson in 1954 while they were in a production of "South Pacific. The marriage produced two children, Heidi and Preston.


Hagman served in the Air Force, spending five years in Europe as the director of USO shows, and on his return to New York he took a starring role in the daytime soap "The Edge of Night." His breakthrough came in 1965 when he landed the "I Dream of Jeannie" role opposite Barbara Eden.


In his later years, Hagman became an advocate for organ transplants and an anti-smoking campaigner. He also was devoted to solar energy, telling the New York Times he had a $750,000 solar panel system at his Ojai estate, and made a commercial in which he portrayed a J.R. Ewing who had forsaken oil for solar power. He was a longtime member of the Peace and Freedom Party, a minor leftist organization in California.


Hagman told the Times that after death he wanted his remains to be "spread over a field and have marijuana and wheat planted and harvest it in a couple of years and then have a big marijuana cake, enough for 200 to 300 people. People would eat a little of Larry."


(Writing by Bill Trott in Washington; Additional reporting by Alex Dobuszinkis in Los Angeles; Editing by Peter Cooney)


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Four new cases of SARS-like virus found in Saudi, Qatar












LONDON (Reuters) – A new virus from the same family as SARS which sparked a global alert in September has now killed two people in Saudi Arabia, and total cases there and in Qatar have reached six, the World Health Organisation said.


The U.N. health agency issued an international alert in late September saying a virus previously unknown in humans had infected a Qatari man who had recently been in Saudi Arabia, where another man with the same virus had died.












On Friday it said in an outbreak update that it had registered four more cases and one of the new patients had died.


“The additional cases have been identified as part of the enhanced surveillance in Saudi Arabia (3 cases, including 1 death) and Qatar (1 case),” the WHO said.


The new virus is known as a coronavirus and shares some of the symptoms of SARS, or Severe Acute Respiratory Syndrome, which emerged in China in 2002 and killed around a 10th of the 8,000 people it infected worldwide.


Among the symptoms in the confirmed cases are fever, coughing and breathing difficulties.


Of the six laboratory-confirmed cases reported to WHO, four cases, including the two deaths, are from Saudi Arabia and two cases are from Qatar.


Britain’s Health Protection Agency, which helped to identify the new virus in September, said the newly reported case from Qatar was initially treated in October in Qatar but then transferred to Germany, and has now been discharged.


Coronaviruses are typically spread like other respiratory infections, such as flu, travelling in airborne droplets when an infected person coughs or sneezes.


The WHO said investigations were being conducted into the likely source of the infection, the method of exposure, and the possibility of human-to-human transmission of the virus.


“Close contacts of the recently confirmed cases are being identified and followed-up,” it said.


It added that so far, only the two most recently confirmed cases in Saudi Arabia were epidemiologically linked – they were from the same family, living in the same household.


“Preliminary investigations indicate that these two cases presented with similar symptoms of illness. One died and the other recovered,” the WHO’s statement said.


Two other members of the same family also suffered similar symptoms of illness, and one died and the other is recovering. But the WHO said laboratory test results on the fatality were still pending, and the person who is recovering had tested negative for the new coronavirus.


The virus has no formal name, but scientists at the British and Dutch laboratories where it was identified refer to it as “London1_novel CoV 2012″.


The WHO urged all its member states to continue surveillance for severe acute respiratory infections.


“Until more information is available, it is prudent to consider that the virus is likely more widely distributed than just the two countries which have identified cases,” it said.


(Editing by Alison Williams)


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